Park Eun Woo (Lee Dong Wook) worked as a doctor in a clinic in Hanoi where he fell in love with a Vietnamese girl Ly Thi Vu (Kim Ok Bin). Due to the sudden death of his father, he had to return to Korea in a hurry but the message wasn't related to Ly Thi Vu. His elder brother Park Sok Woo (Lee Won Jong) who worked as a farmer in the field was hard pressed by his mother to go to Vietnam to find a wife and he ended up bringing Ly Thi Vu to Korea with the intention to marry her. Song Il Lan (Yoo Hye Jung) was Park Sok Woo's childhood friend and she realized that she was in love with him and he had similar feeling for her too. When the misunderstanding between Park Sok Woo and Ly Thi Vu got clarified and all truth were out in the open, his mother who thought Ly Thi Vu was going to be her first son's wife and liked her didn't think she was good enough for her second son as he was a doctor. Ly Thi Vu was hurt and returned to Hanoi. Later the mother came to realize her folly and relented. Park Eun Woo didn't want to give up Ly Thi Vu and so he went back to work in Hanoi and search for her.
Nhân dịp kỷ niệm 30 năm kết thúc chiến tranh ở Việt Nam, đài truyền hình Hàn Quốc SBS đã thực hiện bộ phim truyền hình Cô dâu Hà Nội nói về chuyện tình của cô gái Lý Thị Vũ mang hai dòng máu Việt-Hàn cùng chàng trai Hàn Quốc Eun Woo.
Vì chị gái của Vũ trong quá khứ đã từng bị phụ tình bởi một chàng trai Hàn Quốc nên ra sức ngăn cản mối tình của hai người, khiến Eun Woo phải trở về Hàn Quốc với trái tim tan vỡ.
Không lâu sau đó, anh trai của Eun Woo là Sok Woo sang Việt Nam để tìm kiếm một nửa cho mình và quay trở lại nước với Vũ.
Giờ đây chạm trán lại với nhau, Vũ, Eun Woo và Sok Woo sẽ phải giải quyết như thế nào đây?
